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As far as the inhibition of the most importantlymphokine (IL-2) is concerned, a study of HIV infection and the resulting loss of CD4 Tcells revealed that CD39/73 produced adenosine from Tregs and the resultant induction ofadenyl cyclase activity (cAMP production) induces the inhibition of target T cells todemethylated the CpG site1 region of the IL-2 promoter, which halts IL-2 secretion (Jenabian2013).

This lymphatic tis-sue is the developmental and functional equivalent of thebronchus-associated lymphatic tissue (BALT). The activation process is shown in Rgure F17.4.1. This immediately has several immune suppressing implicationsregarding what was already discussed.